In this work, the effect of temperature on the pressure loss for Newtonian fluid in fully eccentric annulus with pipe rotation is investigated. Extensive experiments with water are conducted at Izmir Katip Celebi University (IKCU), Civil Engineering Department for various flow velocities ranging between 0.7 m/s and 2.9 m/s, pipe rotation range between 0 rpm and 120 rpm. The effect of temperature on frictional pressure losses is also examined, and the temperature is varied from 20 °C to 65 °C. It was observed that, an increase in the fluid temperature in fully eccentric annulus results in a decrease in the pressure gradient. On the other hand, the influence of temperature on pressure gradient becomes more significant, as the Reynolds number is raised. Variation of Taylor number causes negligible changes on frictional pressure losses for all temperature conditions considered. By using regression analysis of the dataset obtained from the experimental work, a simple empirical frictional pressure losses correlation taking into account of temperature effect is proposed. Results showed that a good agreement between the measured and predicted values is achieved with almost 94% coefficient of determination.