This paper focuses on the use of safety barrier analysis, during the design phase of a vessel powered by cryogenic hydrogen, to identify possible weaknesses in the architecture. Barrier analysis can be used to evaluate a series of scenarios that have been identified in the industry as critical. The performance evaluation of such barriers in a specific scenario can lead to either the approval of the design, if a safety threshold is met, or the inclusion of additional barriers to mitigate risk even further. By conducting a structured analysis, it is possible to identify key barriers that need to be included in the system, intended both as physical barriers (sensors, cold box) and as administrative barriers (checklist, operator training). The method chosen for this study is the Barrier and Operational Risk Analysis (BORA) method. This method, developed for the analysis of hydrocarbon releases, is described in the paper and adapted for the analysis of cryogenic hydrogen releases. A case study is presented using the BORA method, developing the qualitative barrier analysis. The qualitative section of the method can be easily adapted to vessels of different class and size adopting the same storage solution. The barrier analysis provides a general framework to analyze the system and check that the safety requirements defined by the ship operator and maritime certification societies are met.