An active subsea field in the Gulf of Mexico has adopted a thermoplastic composite pipe (TCP) water injection jumper for its waterflood upgrade. The jumper assembly is composed of a TCP span attached to steel piping on either end. The TCP spool is lightweight and flexible relative to the traditional steel-only M-shaped subsea jumpers. As such, the flow-induced vibration (FIV) threat from internal fluid flow must be assessed for the intended service. A three-tiered approach is used to assess the level of FIV threat expected in this TCP subsea jumper application. A high-level screening based on widely used industry guidelines indicates a susceptibility to FIV fatigue failure for the steel piping in the TCP jumper assembly. A comprehensive screening based on structural finite element analysis and computational fluid dynamics shows that the vibration levels and stress cycling due to FIV will be acceptable for the intended water injection application and a 30-year design life, when adopting a factor of safety of 10 for subsea service. We evaluate the effect of doubling the length of the steel piping on either end of the TCP span, as a means to increase the overall span of the TCP jumper assembly. Lastly, we draw a comparison between a traditional all-steel M-shaped jumper and the TCP jumper in terms of FIV fatigue life, for the same operating conditions and the same total suspended span.