Despite the 200 billion dollars invested in cancer therapy research and development since 1971, only 5% of new drugs entering clinical trials successfully obtain FDA approval [1, 2]. There is a growing concern in the cancer research community that this slow movement in progress stems from the need for improved preclinical models for testing new therapeutic agents . A burgeoning interface between cancer research and tissue engineering is transforming how tumor development is being studied in vitro. As a result, complex 3D cancer cell culture models are beginning to be developed with phenotypes representative of in vivo cancer progression .
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Characterizing the Phenotypic Response of Endothelial Cells Cultured on Pro-Angiogenic In Vitro Tumor Mimics
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Szot, CS, Buchanan, CF, Freeman, JW, & Rylander, MN. "Characterizing the Phenotypic Response of Endothelial Cells Cultured on Pro-Angiogenic In Vitro Tumor Mimics." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 497-498. ASME. https://doi.org/10.1115/SBC2012-80335
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