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Journal Articles

Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber

Shahab Azimi, Siamak Arzanpour
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2024, 146(4): 041002.
Paper No: BIO-23-1276
https://doi.org/10.1115/1.4064436
Published Online: February 7, 2024
View Article titled, Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber
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Topics: Design, Optimization, Particulate matter, Simulation, Valves, Drugs, Engineering prototypes, Flow (Dynamics), Drug delivery systems
Journal Articles

Novel Payloads to Mitigate Maladaptive Inward Arterial Remodeling in Drug-Coated Balloon Therapy

Tarek Shazly, Mark Uline, Clinton Webb, Breanna Pederson, John F. Eberth, Vijaya B. Kolachalama
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. December 2023, 145(12): 121004.
Paper No: BIO-23-1175
https://doi.org/10.1115/1.4063122
Published Online: September 4, 2023
View Article titled, Novel Payloads to Mitigate Maladaptive Inward Arterial Remodeling in Drug-Coated Balloon Therapy
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Topics: Drugs, Pressure, Surface mount components, Particle filtering (numerical methods), Sheet molding compound (Plastics), Sliding mode control, Performance
Journal Articles

Measurement and Modeling of Transport Across the Blood–Brain Barrier

Hanwen Fan, Qi Cai, Zhenpeng Qin
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Review Articles
J Biomech Eng. August 2023, 145(8): 080802.
Paper No: BIO-22-1314
https://doi.org/10.1115/1.4062737
Published Online: June 20, 2023
View Article titled, Measurement and Modeling of Transport Across the Blood–Brain Barrier
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Topics: Blood, Brain, Drugs
Journal Articles

Biomechanical Response of Cancer Stem Cells to Low-Intensity Ultrasound

Yaozhang Yang, Meng Du, Jinsui Yu, Zhiyi Chen
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. September 2023, 145(9): 091001.
Paper No: BIO-21-1438
https://doi.org/10.1115/1.4062299
Published Online: May 22, 2023
View Article titled, Biomechanical Response of Cancer Stem Cells to Low-Intensity Ultrasound
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Topics: Cancer, Stem cells, Ultrasound, Drugs, Biomechanics, Stiffness
Journal Articles

Evaluation of Soft Mist Inhaler Aerosol Velocity, Size, and Deposition Inside the Mouth—A Computational Fluid Dynamics Study

Taha Sadeghi, Leila Pakzad, Pedram Fatehi
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2023, 145(6): 061007.
Paper No: BIO-22-1147
https://doi.org/10.1115/1.4056967
Published Online: March 8, 2023
View Article titled, Evaluation of Soft Mist Inhaler Aerosol Velocity, Size, and Deposition Inside the Mouth—A Computational Fluid Dynamics Study
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Topics: Aerosols, Computational fluid dynamics, Flow (Dynamics), Geometry, Nozzles, Particulate matter, Drugs
Journal Articles

The Reversal Characteristics of GABAergic Neurons: A Neurovascular Model

Tim David, Robin Morillo, Clare Howarth, Jason Berwick, Llywelyn Lee
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2023, 145(3): 031007.
Paper No: BIO-22-1190
https://doi.org/10.1115/1.4056336
Published Online: December 14, 2022
View Article titled, The Reversal Characteristics of GABAergic Neurons: A Neurovascular Model
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Topics: Computer simulation, Drugs, Electrical conductance, Enzymes, Particle filtering (numerical methods), Sheet molding compound (Plastics), Sliding mode control, Surface mount components, Potassium, Signals
Journal Articles

Using Parallel Coordinates in Optimization of Nano-Particle Drug Delivery

Timoleon Kipouros, Ibrahim Chamseddine, Michael Kokkolaras
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. April 2022, 144(4): 044501.
Paper No: BIO-21-1174
https://doi.org/10.1115/1.4052578
Published Online: November 5, 2021
View Article titled, Using Parallel Coordinates in Optimization of Nano-Particle Drug Delivery
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Topics: Design, Drug delivery systems, Nanoparticles, Optimization, Tumors, Modeling, Drugs
Journal Articles

Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study

Adithya Gurumurthy, Clement Kleinstreuer
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2021, 143(11): 111001.
Paper No: BIO-21-1035
https://doi.org/10.1115/1.4051217
Published Online: July 14, 2021
View Article titled, Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study
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Topics: Aerosols, Drugs, Flow (Dynamics), Nanoparticles, Particulate matter, Lung, Diffusion (Physics), Fluids, Drug delivery systems
Journal Articles

A Dual Nanoparticle Delivery Strategy for Enhancing Drug Distribution in Cancerous Tissue

Ibrahim M. Chamseddine, Michael Kokkolaras
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. December 2020, 142(12): 124501.
Paper No: BIO-19-1462
https://doi.org/10.1115/1.4047657
Published Online: September 8, 2020
View Article titled, A Dual Nanoparticle Delivery Strategy for Enhancing Drug Distribution in Cancerous Tissue
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Topics: Drugs, Nanoparticles, Tumors, Biological tissues, Optimization
Journal Articles

Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport Through Joint Synovium to Measure Effective Diffusivity

Young Guang, Tom M. McGrath, Natalie R. Klug, Robert J. Nims, Chien-Cheng Shih, Peter O. Bayguinov, Farshid Guilak, Christine T. N. Pham, James A. J. Fitzpatrick, Lori A. Setton
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2020, 142(4): 041010.
Paper No: BIO-19-1081
https://doi.org/10.1115/1.4044892
Published Online: December 23, 2019
View Article titled, Combined Experimental Approach and Finite Element Modeling of Small Molecule Transport Through Joint Synovium to Measure Effective Diffusivity
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Topics: Diffusion (Physics), Finite element model, Modeling, Biological tissues, Finite element analysis, Drugs
Journal Articles

Numerical Study of Transport of Anticancer Drugs in Heterogeneous Vasculature of Human Brain Tumors Using Dynamic Contrast Enhanced-Magnetic Resonance Imaging

Ajay Bhandari, Ankit Bansal, Anup Singh, Niraj Sinha
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. May 2018, 140(5): 051010.
Paper No: BIO-17-1366
https://doi.org/10.1115/1.4038746
Published Online: March 16, 2018
View Article titled, Numerical Study of Transport of Anticancer Drugs in Heterogeneous Vasculature of Human Brain Tumors Using Dynamic Contrast Enhanced-Magnetic Resonance Imaging
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Topics: Drugs, Tumors
Journal Articles

Nanoparticle Optimization for Enhanced Targeted Anticancer Drug Delivery

Ibrahim M. Chamseddine, Michael Kokkolaras
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2018, 140(4): 041002.
Paper No: BIO-17-1243
https://doi.org/10.1115/1.4038202
Published Online: January 19, 2018
View Article titled, Nanoparticle Optimization for Enhanced Targeted Anticancer Drug Delivery
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Topics: Drugs, Nanoparticles, Optimization, Tumors, Design, Vessels, Shapes
Journal Articles

The Localized Hemodynamics of Drug-Eluting Stents Are Not Improved by the Presence of Magnetic Struts

P. R. S. Vijayaratnam, T. J. Barber, J. A. Reizes
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. January 2017, 139(1): 014502.
Paper No: BIO-16-1150
https://doi.org/10.1115/1.4035263
Published Online: November 30, 2016
View Article titled, The Localized Hemodynamics of Drug-Eluting Stents Are Not Improved by the Presence of Magnetic Struts
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Topics: Blood, Drugs, Hemodynamics, Magnetic induction, Magnets, Stents, Struts (Engineering), Vessels, Magnetic fields, Flow (Dynamics)
Journal Articles

Macroscopic Modeling of In Vivo Drug Transport in Electroporated Tissue

Bradley Boyd, Sid Becker
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2016, 138(3): 031008.
Paper No: BIO-15-1359
https://doi.org/10.1115/1.4032380
Published Online: February 5, 2016
View Article titled, Macroscopic Modeling of In Vivo Drug Transport in Electroporated Tissue
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Topics: Biological tissues, Drugs, Electrical conductivity, Electroporation, Electric fields, Transients (Dynamics)
Journal Articles

Computational Investigation of Drug Action on Human-Induced Stem Cell-Derived Cardiomyocytes

Ralf Frotscher, Jan-Peter Koch, Manfred Staat
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. July 2015, 137(7): 071002.
Paper No: BIO-14-1593
https://doi.org/10.1115/1.4030173
Published Online: July 1, 2015
View Article titled, Computational Investigation of Drug Action on Human-Induced Stem Cell-Derived Cardiomyocytes
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Topics: Drugs, Simulation, Biological tissues
Journal Articles

Enhanced Targeted Drug Delivery Through Controlled Release in a Three-Dimensional Vascular Tree

Shuang J. Zhu, Eric K. W. Poon, Andrew S. H. Ooi, Stephen Moore
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2015, 137(3): 031002.
Paper No: BIO-13-1410
https://doi.org/10.1115/1.4028965
Published Online: March 1, 2015
View Article titled, Enhanced Targeted Drug Delivery Through Controlled Release in a Three-Dimensional Vascular Tree
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Topics: Drugs, Particulate matter, Simulation, Flow (Dynamics), Drug delivery systems, Algorithms, Modeling
Journal Articles

Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery

Xiaoxiang Zhu, Richard D. Braatz
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2014, 136(11): 111004.
Paper No: BIO-14-1169
https://doi.org/10.1115/1.4028135
Published Online: September 4, 2014
View Article titled, Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery
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Topics: Coating processes, Coatings, Drugs, PLGA, Stents, Struts (Engineering), Drug delivery systems
Journal Articles

Influence of Hyperthermia on Efficacy and Uptake of Carbon Nanohorn-Cisplatin Conjugates

Matthew R. DeWitt, Allison M. Pekkanen, John Robertson, Christopher G. Rylander, Marissa Nichole Rylander
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2014, 136(2): 021003.
Paper No: BIO-13-1471
https://doi.org/10.1115/1.4026318
Published Online: February 5, 2014
View Article titled, Influence of Hyperthermia on Efficacy and Uptake of Carbon Nanohorn-Cisplatin Conjugates
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Topics: Carbon, Drugs, Heat, Nanoparticles, Tumors, Temperature, Heating, Particulate matter, Patient treatment, Diffusion (Physics)
Journal Articles

Development of Chitosan and Polylactic Acid Based Methotrexate Intravitreal Micro-Implants to Treat Primary Intraocular Lymphoma: An In Vitro Study

Soumyarwit Manna, James J. Augsburger, Zelia M. Correa, Julio A. Landero, Rupak K. Banerjee
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. February 2014, 136(2): 021018.
Paper No: BIO-13-1349
https://doi.org/10.1115/1.4026176
Published Online: February 5, 2014
View Article titled, Development of Chitosan and Polylactic Acid Based Methotrexate Intravitreal Micro-Implants to Treat Primary Intraocular Lymphoma: An In Vitro Study
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Topics: Drugs, Coating processes, Coatings, Polymers
Journal Articles

Development of Characteristic Upper Tracheobronchial Airway Models for Testing Pharmaceutical Aerosol Delivery

Ross L. Walenga, Geng Tian, P. Worth Longest
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. September 2013, 135(9): 091010.
Paper No: BIO-13-1011
https://doi.org/10.1115/1.4024630
Published Online: July 10, 2013
View Article titled, Development of Characteristic Upper Tracheobronchial Airway Models for Testing Pharmaceutical Aerosol Delivery
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Topics: Aerosols, Computational fluid dynamics, Drugs, Flow (Dynamics), Particulate matter, Simulation, Trachea, Bifurcation, Geometry, Testing