Parameters optimization is complicated by various parameters and nonlinear design problems. In this paper, the interaction mechanism of motion/force transmissibility and various parameters on normalized motor torque and speed of a four degrees-of-freedom (4-DOF) high-speed parallel robot is analyzed. Based on this interaction mechanism, evaluation indices of acceleration capacity, speed ability, and adept cycle time are proposed. Through combining these indices with task requirements and technical criteria of driving systems, the technology-oriented constraints are set up and a parameter optimization method is proposed. With this method, the dimensional parameters, driving system specifications, and work pose of the robot have been synchronously optimized to ensure low driving torque and high pick-and-place frequency. This synchronous optimal design method is general and can be further applied to parameter optimization for different types of parallel robots.